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COG is currently a OGC draft candidate (http://docs.ogc.org/DRAFTS/21-026.html).
COG-aware software is available both from the perspective of a data provider and data user. Currently tools that offer COG support include:
Geoserver: An open source geospatial data server offers a COG plugin that enables COG support to existing data stores. The plug in allows for image index configuration as well as range reading capability for HTTP and some standard cloud architectures.
QGIS: An open source desktop Geographic Information System (GIS)
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